| Date | Home | Away | Result |
|---|---|---|---|
| 8/15/25 11:00 AM | FC Empoli | AC Reggiana 1919 | 4-1a.PSO |
| 8/15/25 11:30 AM | Sassuolo Calcio | US Catanzaro 1929 | 1-0 |
| 8/15/25 1:45 PM | US Lecce | Juve Stabia | 2-0 |
| 8/15/25 2:15 PM | Genoa CFC | Vicenza Calcio | 3-0 |
| 8/16/25 11:00 AM | FC Venice | Mantova 1911 | 4-0 |
| 8/16/25 11:30 AM | Como Calcio | FC Südtirol | 3-1 |
| 8/16/25 1:45 PM | Cagliari Calcio | Virtus Entella | 6-5a.PSO |
| 8/16/25 2:15 PM | US Cremonese | Palermo FC | 4-5a.PSO |
| 8/17/25 11:00 AM | AC Monza | Frosinone Calcio | 0-1 |
| 8/17/25 11:30 AM | Parma Calcio 1913 | Pescara Calcio | 2-0 |
| 8/17/25 1:45 PM | FC Cesena | Pisa Sporting Club | 1-2a.PSO |
| 8/17/25 2:15 PM | AC Milan | SSC Bari | 2-0 |
| 8/18/25 11:00 AM | Audace Cerignola | Hellas Verona | 3-5a.PSO |
| 8/18/25 11:30 AM | Spezia Calcio | Sampdoria Genua | 5-3a.PSO |
| 8/18/25 1:45 PM | Udinese Calcio | Carrarese Calcio 1908 | 2-0 |
| 8/18/25 2:15 PM | FC Turin | Modena FC | 1-0 |